XENOBIOTIC-METABOLIZING ENZYME-SYSTEMS IN TEST FISH .1. COMPARATIVE-STUDIES OF LIVER MICROSOMAL MONOOXYGENASES

被引：31

作者：

FUNARI, E ^{[1
]}

ZOPPINI, A ^{[1
]}

VERDINA, A ^{[1
]}

DEANGELIS, G ^{[1
]}

VITTOZZI, L ^{[1
]}

机构：

[1] IST SUPER SANITA, TOSSICOL COMPARATA & ECOTOSSICOL LAB, VIALE REGINA ELENA 299, I-00161 ROME, ITALY

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 1987年 / 13卷 / 01期

关键词：

D O I：

10.1016/0147-6513(87)90039-X

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

All monooxygenase activities assayed in guppy (Poecilia reticulata) and red killifish (Oryzias latipes) were 7-10 times higher than those measured in trout (Salmo gairdneri), carp (Cyprinus carpio), and golden orfe (Leuciscus idus). Cytochrome P-450 was 3 times higher in the former fish than in all the other species. Zebra fish (Brachydanio rerio) 7-ethoxycoumarin O-deethylase and bluegill (Lepomis macrochirus) ethylmorphine N-demethylase (EMND) were not greatly different from those of the former group. .alpha.-Naphthoflavone (NF) and methyrapone (MET) exerted qualitatively different actions on benzo[a]pyrene hydroxylase of guppy, trout, and bluegill liver: both chemicals enhanced the bluegill activity and inhibited that of trout; the guppy liver enzyme was inhibited by MET and activated by NF. EMND activity was inhibited by either compound in the three species. The relevance of all these data to the European Economic Community ecotoxicity tests is discussed.

引用

页码：24 / 31

页数：8

共 18 条

[1]

ANDERS MW, 1966, MOL PHARMACOL, V2, P319

[2] INDUCTION AND CHARACTERIZATION OF HEMOPROTEIN(S) P-450 AND MONOOXYGENATION IN RAINBOW-TROUT (SALMO-GAIRDNERI) [J].