VIRUS INACTIVATION DURING PRODUCTION OF INTRAVENOUS IMMUNOGLOBULIN

被引：43

作者：

KEMPF, C

JENTSCH, P

POIRIER, B

BARRESINOUSSI, F

MORGENTHALER, JJ

MORELL, A

GERMANN, D

机构：

[1] INST PASTEUR,BIOL RETROVIRUS LAB,PARIS,FRANCE

[2] SWISS RED CROSS,BLOOD TRANSFUS SERV,DEPT RES,CENT LAB,CH-3000 BERN 22,SWITZERLAND

[3] UNIV BERN,INST MED MICROBIOL,CH-3012 BERN,SWITZERLAND

[4] SWISS RED CROSS,BLOOD TRANSFUS SERV,DEPT MED,CENT LAB,CH-3000 BERN 22,SWITZERLAND

来源：

TRANSFUSION | 1991年 / 31卷 / 05期

关键词：

D O I：

10.1046/j.1537-2995.1991.31591263197.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of pepsin treatment at pH 4 on the infectivity of several enveloped viruses was assessed under the conditions used during the production of intravenous immunoglobulins. It was shown that the prototypes of four virus families - human immunodeficiency virus (Lentivirinae), herpes simplex virus type 1 and human cytomegalovirus (Herpesviridae), Semliki Forest virus (Togaviridae), and vesicular stomatitis virus (Rhabdoviridae) - were inactivated by this procedure. With vesicular stomatitis virus as a model, the contributions of both low pH and pepsin were demonstrated, and pepsin had a synergistic or additive action.

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页码：423 / 427

页数：5

相关论文

共 25 条

[1] DETECTION OF ANTIBODY TO HEPATITIS-C VIRUS IN PROSPECTIVELY FOLLOWED TRANSFUSION RECIPIENTS WITH ACUTE AND CHRONIC NON-A-HEPATITIS, NON-B-HEPATITIS [J].

ALTER, HJ ;

PURCELL, RH ;

SHIH, JW ;

MELPOLDER, JC ;

HOUGHTON, M ;

CHOO, QL ;

KUO, G .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) :1494-1500

[2] INTRAVENOUS IMMUNOGLOBULIN PROPHYLAXIS CAUSING LIVER-DAMAGE IN 16 OF 77 PATIENTS WITH HYPOGAMMAGLOBULINEMIA OR IGG SUBCLASS DEFICIENCY [J].

BJORKANDER, J ;

CUNNINGHAMRUNDLES, C ;

LUNDIN, P ;

OLSSON, R ;

SODERSTROM, R ;

HANSON, LA .

AMERICAN JOURNAL OF MEDICINE, 1988, 84 (01) :107-111

[3] ISOLATION OF A CDNA CLONE DERIVED FROM A BLOOD-BORNE NON-A, NON-B VIRAL-HEPATITIS GENOME [J].

CHOO, QL ;

KUO, G ;

WEINER, AJ ;

OVERBY, LR ;

BRADLEY, DW ;

HOUGHTON, M .

SCIENCE, 1989, 244 (4902) :359-362

[4] PLASMA VIREMIA IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTION [J].

COOMBS, RW ;

COLLIER, AC ;

ALLAIN, JP ;

NIKORA, B ;

LEUTHER, M ;

GJERSET, GF ;

COREY, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (24) :1626-1631

[5] ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) ASSOCIATED WITH TRANSFUSIONS [J].

CURRAN, JW ;

LAWRENCE, DN ;

JAFFE, H ;

KAPLAN, JE ;

ZYLA, LD ;

CHAMBERLAND, M ;

WEINSTEIN, R ;

LUI, KJ ;

SCHONBERGER, LB ;

SPIRA, TJ ;

ALEXANDER, WJ ;

SWINGER, G ;

AMMANN, A ;

SOLOMON, S ;

AUERBACH, D ;

MILDVAN, D ;

STONEBURNER, R ;

JASON, JM ;

HAVERKOS, HW ;

EVATT, BL .

NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (02) :69-75

[6]

FINLAYSON JS, 1988, IMMUNOGLOBULINS, P231

[7] RAPID DETECTION OF CYTOMEGALOVIRUS IN MRC-5-CELLS INOCULATED WITH URINE SPECIMENS BY USING LOW-SPEED CENTRIFUGATION AND MONOCLONAL-ANTIBODY TO AN EARLY ANTIGEN [J].

GLEAVES, CA ;

SMITH, TF ;

SHUSTER, EA ;

PEARSON, GR .

JOURNAL OF CLINICAL MICROBIOLOGY, 1984, 19 (06) :917-919

[8] DETECTION AND SEROTYPING OF HERPES-SIMPLEX VIRUS IN MRC-5 CELLS BY USE OF CENTRIFUGATION AND MONOCLONAL-ANTIBODIES 16-H POSTINOCULATION [J].

GLEAVES, CA ;

WILSON, DJ ;

WOLD, AD ;

SMITH, TF .

JOURNAL OF CLINICAL MICROBIOLOGY, 1985, 21 (01) :29-32

[9] INFECTION OF HTLV-III/LAV IN HTLV-I-CARRYING CELLS MT-2 AND MT-4 AND APPLICATION IN A PLAQUE-ASSAY [J].

HARADA, S ;

KOYANAGI, Y ;

YAMAMOTO, N .

SCIENCE, 1985, 229 (4713) :563-566

[10] INACTIVATION AND PARTITION OF HUMAN IMMUNODEFICIENCY VIRUS DURING KISTLER AND NITSCHMANN FRACTIONATION OF HUMAN-BLOOD PLASMA [J].

HENIN, Y ;

MARECHAL, V ;

BARRESINOUSSI, F ;

CHERMANN, JC ;

MORGENTHALER, JJ .

VOX SANGUINIS, 1988, 54 (02) :78-83