DETECTION OF HUMAN PAPILLOMAVIRUS (HPV) IN LARYNXPAPILLOMAS - A INSITU HYBRIDIZATION STUDY

被引：6

作者：

ARNDT, O

ZEISE, K

BAUER, I

BROCK, J

机构：

来源：

LARYNGO-RHINO-OTOLOGIE | 1992年 / 71卷 / 03期

关键词：

D O I：

10.1055/s-2007-997263

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Together 35 papillomas of the larynx (8 juvenils, 27 adults) were studied for the presence of HPV-DNA by means of nucleic acid hybridization. The hybridization procedure was carried out "in situ" with biotinylated probes of HPV 6/11 and 16/18 under stringent conditions. The results are shown in Table 1. In all juvenile papillomas we detected HPV 6/11, but we did not find positive signals after hybridization with HPV 16/18. 25 (92,6%) of the examinated adult papillomas were HPV 6/11 positiv. The detection procedure of HPV 16/18 was positiv twice (11,8%). The results of our studie support the hypothesis of HPV 6/11 in development of larynxpapillomas.

引用

页码：132 / 136

页数：5