MORPHOLOGICAL-CHANGES OF HUMAN MYELOID-LEUKEMIA K562 CELLS BY A PROTEIN PHOSPHATASE INHIBITOR, TAUTOMYCIN

被引：28

作者：

MAGAE, J

OSADA, H

FUJIKI, H

SAIDO, TC

SUZUKI, K

NAGAI, K

YAMASAKI, M

ISONO, K

机构：

[1] INST PHYS & CHEM RES,ANTIBIOT LAB,WAKO,SAITAMA 35101,JAPAN

[2] NATL CANC CTR,RES INST,DIV CANC PREVENT,CHUO KU,TOKYO 104,JAPAN

[3] TOKYO METROPOLITAN INST MED SCI,DEPT MOLEC BIOL,BUNKYO KU,TOKYO 113,JAPAN

[4] UNIV TOKYO,DEPT AGR CHEM,MICROBIOL LAB,BUNKYO KU,TOKYO 113,JAPAN

来源：

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 1990年 / 66卷 / 10期

关键词：

TAUTOMYCIN; PROTEIN PHOSPHATASE; OKADAIC ACID;

D O I：

10.2183/pjab.66.209

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An antibiotic, tautomycin induced bled formation and protein phosphorylation of K562 cells as do the protein phosphatase inhibitors, okadaic acid and dinophysistoxin-1. Tautomycin inhibited the specific binding of [H-3]okadaic acid to protein phosphatases. Furthermore, tautomycin inhibited the protein phosphatases isolated from mouse brain. However, tautomycin did not activate the protein kinase C. These results indicate that tautomycin induces bled formation through inhibition of protein phosphatases.

引用

收藏

页码：209 / 212

页数：4

相关论文

共 14 条

[1] A NEW ANTIBIOTIC, TAUTOMYCIN [J].

CHENG, XC ;

KIHARA, T ;

KUSAKABE, H ;

MAGAE, J ;

KOBAYASHI, Y ;

FANG, RP ;

NI, ZF ;

SHEN, YC ;

KO, K ;

YAMAGUCHI, I ;

ISONO, K .

JOURNAL OF ANTIBIOTICS, 1987, 40 (06) :907-909

[2] DIARRHETIC SHELLFISH TOXIN, DINOPHYSISTOXIN-1, IS A POTENT TUMOR PROMOTER ON MOUSE SKIN [J].

FUJIKI, H ;

SUGANUMA, M ;

SUGURI, H ;

YOSHIZAWA, S ;

TAKAGI, K ;

UDA, N ;

WAKAMATSU, K ;

YAMADA, K ;

MURATA, M ;

YASUMOTO, T ;

SUGIMURA, T .

JAPANESE JOURNAL OF CANCER RESEARCH, 1988, 79 (10) :1089-1093

[3] THE PROTEIN PHOSPHATASES INVOLVED IN CELLULAR-REGULATION .1. CLASSIFICATION AND SUBSTRATE SPECIFICITIES [J].

INGEBRITSEN, TS ;

COHEN, P .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1983, 132 (02) :255-261

[4] THE BIOACTIVE MARINE METABOLITES .16. CALYCULIN-A, A NOVEL ANTITUMOR METABOLITE FROM THE MARINE SPONGE DISCODERMIA-CALYX [J].

KATO, Y ;

FUSETANI, N ;

MATSUNAGA, S ;

HASHIMOTO, K ;

FUJITA, S ;

FURUYA, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (10) :2780-2781

[5]

Kitano T, 1986, Methods Enzymol, V124, P349

[6] ENZYMATIC-PROPERTIES OF A NOVEL PHORBOL ESTER RECEPTOR PROTEIN-KINASE, NPKC [J].

KONNO, Y ;

OHNO, S ;

AKITA, Y ;

KAWASAKI, H ;

SUZUKI, K .

JOURNAL OF BIOCHEMISTRY, 1989, 106 (04) :673-678

[7] COMPARISON OF THE EFFECT OF TAUTOMYCIN AND PHORBOL ESTER ON PROTEIN KINASE-C IN A CELL-FREE SYSTEM [J].

MAGAE, J ;

OSADA, H ;

NAGAI, K ;

YAMASAKI, M ;

ISONO, K .

JOURNAL OF ANTIBIOTICS, 1989, 42 (08) :1290-1293

[8] INDUCTION OF MORPHOLOGICAL CHANGE OF HUMAN MYELOID-LEUKEMIA AND ACTIVATION OF PROTEIN-KINASE C BY A NOVEL ANTIBIOTIC, TAUTOMYCIN [J].

MAGAE, J ;

WATANABE, C ;

OSADA, H ;

CHENG, XC ;

ISONO, K .

JOURNAL OF ANTIBIOTICS, 1988, 41 (07) :932-937

[9] RAPID SCREENING METHOD FOR INHIBITORS OF PROTEIN KINASE-C [J].

OSADA, H ;

MAGAE, J ;

WATANABE, C ;

ISONO, K .

JOURNAL OF ANTIBIOTICS, 1988, 41 (07) :925-931

[10] APPARENT ACTIVATION OF PROTEIN-KINASES BY OKADAIC ACID CLASS TUMOR PROMOTERS [J].

SASSA, T ;

RICHTER, WW ;

UDA, N ;

SUGANUMA, M ;

SUGURI, H ;

YOSHIZAWA, S ;

HIROTA, M ;

FUJIKI, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 159 (03) :939-944