N-(5-FLUOROBENZOTHIAZOL-2-YL)-2-GUANIDINOTHIAZOLE-4-CARBOXAMIDE - A NOVEL, SYSTEMICALLY ACTIVE ANTITUMOR AGENT EFFECTIVE AGAINST 3LL LEWIS LUNG-CARCINOMA

N-(5-Fluorobenzothiazol-2-yl)-2-guanidinothiazole-4-carboxamide (1) is a member of a series of amides found to substantially increase lifespan in mice bearing established micrometastatic 3LL Lewis lung carcinoma. Amide 1 is effective after either oral or intraperitoneal dosing in acute, subacute, or chronic regimens. 1 is well tolerated in this model with an excellent therapeutic index relative to the cytotoxic anticancer drug adriamycin.