STEREOSPECIFIC SYNTHESIS OF THE ENANTIOMERS OF NICOTINYLALANINE, A NEUROPROTECTING AGENT

被引：12

作者：

PELLICCIARI, R

GALLOMEZO, MA

NATALINI, B

AMER, AM

机构：

[1] Istituto di Chimica Farmaceutica e Tecnica Farmaceutica, Università degli Studi, Perugia

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 21期

关键词：

STEREOSPECIFIC SYNTHESIS; ENANTIOMER; NEURODEGENERATIVE DISORDERS; NEUROPROTECTIVE; ENZYME INHIBITOR;

D O I：

10.1016/S0040-4039(00)79583-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereospecific synthesis of the title compounds has been achieved in > 95% ee by use of palladium-catalyzed cross-coupling of S- and R-(3-benzyloxycarbonyl-5-oxo-4-oxazolidinyl)-acetyl chloride, respectively, with 3-trimethylstannyl pyridine at room temperature.

引用

页码：3003 / 3004

页数：2

共 14 条

[1]

BAILEY TR, 1991, SYNTHESIS-STUTTGART, P242

[2]

DECKER RH, 1963, J BIOL CHEM, V238, P1049

[3]

FERINGA BL, 1986, J ORG CHEM, V51, P5486

[4] SYNTHESIS OF HYDROXYCOTININE AND STUDIES ON ITS STRUCTURE [J].