CHOLERETIC EFFECT OF ANDROGRAPHOLIDE IN RATS AND GUINEA-PIGS

被引：60

作者：

SHUKLA, B ^{[1
]}

VISEN, PKS ^{[1
]}

PATNAIK, GK ^{[1
]}

DHAWAN, BN ^{[1
]}

机构：

[1] CENT DRUG RES INST,INDIAN COUNCIL MED RES,CTR ADV PHARMACOL RES TRADIT REMEDIES,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

PLANTA MEDICA | 1992年 / 58卷 / 02期

关键词：

ANDROGRAPHIS-PANICULATA; ANDROGRAPHOLIDE; CHOLERETIC ACTIVITY; HEPATOPROTECTIVE EFFECTS;

D O I：

10.1055/s-2006-961416

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Andrographolide from the herb Andrographis paniculata (whole plant) per se produces a significant dose (1.5-12 mg/kg) dependent choleretic effect (4.8-73%) as evidenced by increase in bile flow, bile salt, and bile acids in conscious rats and anaesthetized guinea pigs. The paracetamol induced decrease in volume and contents of bile was prevented significantly by andrographolide pretreatment. It was found to be more potent than silymarin, a clinically used hepatoprotective agent.

引用

页码：146 / 149

页数：4

共 18 条

[1]

Boorsma WA, 1896, MEDS LANDS PLANT, V18, P63

[2] STUDIES ON BILE SECRETION WITH AID OF ISOLATED PERFUSED RAT-LIVER .1. INHIBITORY ACTION OF SPORIDESMIN AND ICTEROGENIN [J].