SYNTHESIS OF 4-DEOXYAKLANONIC ACID AND ITS MICROBIAL CONVERSION INTO ANTHRACYCLINONES

被引：10

作者：

KROHN, K ^{[1
]}

ROEMER, E ^{[1
]}

TOP, M ^{[1
]}

WAGNER, C ^{[1
]}

机构：

[1] HANS KNOLL INST NAT FORSCH EV,D-07745 JENA,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1993年 / 32卷 / 08期

关键词：

D O I：

10.1002/anie.199311511

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

With a mutant strain of Streptomyces galilaeus, a cinerubin producer, the unnatural 4-deoxyaklanoic acid 1 can be converted into the enantiomerically pure 4-deoxyaklavinones 2 and 3. Through this combination of chemical synthesis and multistep biotransformation, the preparation of glycosidic anthracyclines should be possible, for which improved antitumor properties are expected.

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页码：1151 / 1152

页数：2

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