IMMUNE AND NEUROENDOCRINE RESPONSE TO RESTRAINT IN MALE AND FEMALE RATS

被引：18

作者：

FARABOLLINI, F

ALBONETTI, ME

ALOISI, AM

FACCHINETTI, F

GRASSO, G

LODI, L

LUPO, C

MUSCETTOLA, M

机构：

[1] UNIV SIENA,IST ANAT UMANA NORMALE,I-53100 SIENA,ITALY

[2] UNIV SIENA,IST FISIOL GEN & SCI ALIMENTAZ,I-53100 SIENA,ITALY

[3] UNIV MODENA,OSTET & GINECOL CLIN,I-41100 MODENA,ITALY

来源：

PSYCHONEUROENDOCRINOLOGY | 1993年 / 18卷 / 03期

关键词：

D O I：

10.1016/0306-4530(93)90002-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A parallel study of the modification in the opioid and immunological systems induced by acute restraint (RT) was carried out in male and female rats 24 hr after the treatment. Beta-endorphin-like immunoreactivity (beta-ELI) was measured in two brain areas (ventral hypothalamus [HYP] and periaqueductal gray matter [PAG]) and in the pituitary (anterior and neurointermediate lobes), together with plasma corticosterone (C) and ACTH. Immune function was measured as mitogen-induced Interferon-gamma (IFN-gamma) production by splenocytes. RT reduced beta-ELI levels in the PAG in males and females. Plasma levels of C and ACTH did not differ from the basal levels in restrained animals. RT reduced IFN-gamma production in both sexes, but this effect was more marked in females than in males. The possible relationship between the immune and opioid system is discussed.

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收藏

页码：175 / 182

页数：8

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