SYNTHESIS OF SUBSTITUTED HETEROCYCLES - SIMPLE METHOD FOR THE INTRODUCTION OF THE N-HYDROXYUREA FUNCTIONALITY

被引：15

作者：

KU, YY

PATEL, RR

RODEN, BA

SAWICK, DP

机构：

[1] Chemical and Agricultural Products Division Abbott Laboratories, North Chicago

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 33期

关键词：

D O I：

10.1016/0040-4039(94)88063-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple method for the introduction of the N-hydroxyurea functionality has been developed. This involves conjugate addition of hydroxylamine to a vinylsulfone substrate. This method was successfully used in a facile synthesis of the 5-lipoxygenase inhibitors, zileuton and A-69412.

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页码：6017 / 6020

页数：4

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