CONTRIBUTION OF CALCIUM-IONS TO THE GENERATION OF EPILEPTIC ACTIVITY AND ANTIEPILEPTIC CALCIUM ANTAGONISM

被引：30

作者：

SPECKMANN, EJ ^{[1
]}

STRAUB, H ^{[1
]}

KOHLING, R ^{[1
]}

机构：

[1] INST EXPTL EPILEPSIEFORSCH,MUNSTER,GERMANY

来源：

NEUROPSYCHOBIOLOGY | 1993年 / 27卷 / 03期

关键词：

EPILEPSY; ORGANIC CALCIUM CHANNEL BLOCKERS; VERAPAMIL; FLUNARIZINE;

D O I：

10.1159/000118966

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

With epileptic activity, neurons show paroxysmal depolarization shifts (PDSs) corresponding to epileptic field potentials (EFPs) generated by the neuronal population. Experimental results indicate that calcium and calcium-dependent currents participate in the generation of these events. Consequently neuronal PDS/EFP were depressed by organic calcium channel blockers. This justifies the hope that calcium channel blockers might be useful in the treatment of human epilepsies.

引用

页码：122 / 126

页数：5

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