EFFECTS OF INTERLEUKIN-1-BETA AND INTERLEUKIN-2 ON AMINO-ACIDS LEVELS IN MOUSE CORTEX AND HIPPOCAMPUS

被引：19

作者：

BIANCHI, M

FERRARIO, P

ZONTA, N

PANERAI, AE

机构：

[1] Department of Pharmacology, University of Milano, Milano, 20129

来源：

NEUROREPORT | 1995年 / 6卷 / 12期

关键词：

INTERLEUKIN-1; INTERLEUKIN-2; NEUROTRANSMITTER AMINO ACIDS;

D O I：

10.1097/00001756-199508000-00023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE measured the levels of glutamine, aspartic acid, glutamic acid and GABA in cortex and hippocampus of mice acutely treated with i.p. human recombinant interleukin-2 (IL-2) or human remombinant interleukin-1 beta (IL-1 beta). Administration of IL-2 (5.0 mu g kg(-1)) induced a slight but statistically significant increase in glutamine concentrations in both brain areas, while similar administration of IL-1 beta (20 mu g kg(-1)) significantly reduced the hippocampal levels of glutamine, glutamic acid and GABA. Our data suggest that brain amino acid pathways are involved in the central modifications induced by IL-1 beta.

引用

页码：1689 / 1692

页数：4

共 25 条

[1] THE INTERLEUKIN-1-ALPHA, INTERLEUKIN-1-ALPHA, AND INTERLEUKIN-2 DO NOT ACUTELY DISRUPT THE MURINE BLOOD-BRAIN-BARRIER [J].