INFLUENCE OF HIV ANTIGENS ON FUNCTIONAL-ACTIVITY OF NEUTROPHILIC GRANULOCYTES IN PATIENTS WITH HIV-INFECTION

被引：12

作者：

GABRILOVICH, DI ^{[1
]}

KOZHICH, AT ^{[1
]}

SUVOROVA, ZK ^{[1
]}

IVANOV, VS ^{[1
]}

MOSHNIKOV, SA ^{[1
]}

CHIKIN, LD ^{[1
]}

KOLEZONKOVA, OV ^{[1
]}

POKROVSKY, VV ^{[1
]}

机构：

[1] MM SHEMYAKIN BIOORGAN CHEM INST,MOSCOW 117312,USSR

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1991年 / 33卷 / 05期

关键词：

D O I：

10.1111/j.1365-3083.1991.tb02525.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of nine HIV antigens, including eight synthetic peptides, on the functional activity of granulocytes was studied using the reduction of nitroblue tetrazolium test (NBT test). Some peptides partly suppressed the functional activity of granulocytes. The most pronounced suppression was caused by ImVL (HIV-1 lysate immobilized on plates for ELISA) and SP-7 (a synthetic peptide from the gp41 protein of HIV-1). The degrees to which the functional activity of granulocytes was suppressed by ImVL and SP-7 was in inverse proportion to the specific antibody concentrations. No correlation was found between the reduction in the NBT test value and the amount of CD4+, CD8+ cells on CD4/8 ratio.

引用

页码：549 / 552

页数：4

共 15 条

[1] THE RESPIRATORY BURST OF PHAGOCYTES [J].