LITHIUM EFFECTS ON NORADRENERGIC-LINKED ADENYLATE-CYCLASE ACTIVITY IN INTACT RAT-BRAIN - AN INVIVO MICRODIALYSIS STUDY

被引：40

作者：

MASANA, MI

BITRAN, JA

HSIAO, JK

MEFFORD, IN

POTTER, WZ

机构：

[1] Section of Clinical Pharmacology, Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda

来源：

BRAIN RESEARCH | 1991年 / 538卷 / 02期

关键词：

LITHIUM; CYCLIC ADENOSINE MONOPHOSPHATE; BETA-RECEPTOR; INVIVO MICRODIALYSIS; NOREPINEPHRINE;

D O I：

10.1016/0006-8993(91)90450-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of chronic lithium treatment on adenylate cyclase activity in intact rat brain were examined using in vivo microdialysis. Basal extracellular cyclic adenosine monophosphate (AMP) increased in a dose-dependent manner after norepinephrine was added to the perfusate. Chronic lithium treatment increased basal brain extracellular fluid cyclic AMP levels, while decreasing the magnitude of the cyclic AMP response to stimulation with 100-mu-M norepinephrine.

引用

页码：333 / 336

页数：4

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