CIRCULATING INTEGRINS - ALPHA-5-BETA-1, ALPHA-6-BETA-4 AND MAC-1, BUT NOT ALPHA-3-BETA-1, ALPHA-4-BETA-1 OR LFA-1

被引：200

作者：

BRETSCHER, MS

机构：

[1] Medical Research Council, Lab. of Molecular Biology, Cambridge, Hills Road

来源：

EMBO JOURNAL | 1992年 / 11卷 / 02期

关键词：

CELL LOCOMOTION; CELL RECOGNITION; CELL SURFACE RECEPTORS; ENDOCYTOSIS; INTEGRINS;

D O I：

10.1002/j.1460-2075.1992.tb05068.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The alpha-5-beta-1, alpha-6-beta-4 and Mac-1 integrins all participate in the endocytotic cycle. By contrast, alpha-3-beta-1, alpha-4-beta-1 and LFA-1 do so much more slowly, or not at all, in the cell lines examined. This indicates that the alpha-chains appear to determine whether an integrin cycles or not, and that alpha-5-beta-1, alpha-6-beta-4 and Mac-1 can be brought to the leading edge of a moving cell by endocytosis and recycling.

引用

收藏

页码：405 / 410

页数：6

相关论文

共 41 条

[1]

LEUKOCYTE ADHESION DEFICIENCY - AN INHERITED DEFECT IN THE MAC-1, LFA-1, AND P150,95 GLYCOPROTEINS [J].

ANDERSON, DC ;

SPRINGER, TA .

ANNUAL REVIEW OF MEDICINE, 1987, 38 :175-194

[2]

AMINO-ACID-SEQUENCE OF THE HUMAN FIBRONECTIN RECEPTOR [J].

ARGRAVES, WS ;

SUZUKI, S ;

ARAI, H ;

THOMPSON, K ;

PIERSCHBACHER, MD ;

RUOSLAHTI, E .

JOURNAL OF CELL BIOLOGY, 1987, 105 (03) :1183-1190

[3]

DEFICIENCY OF A LEUKOCYTE SURFACE GLYCOPROTEIN (LFA-1) IN 2 PATIENTS WITH MO1 DEFICIENCY - EFFECTS OF CELL ACTIVATION ON MO1 LFA-1 SURFACE EXPRESSION IN NORMAL AND DEFICIENT LEUKOCYTES [J].

ARNAOUT, MA ;

SPITS, H ;

TERHORST, C ;

PITT, J ;

TODD, RF .

JOURNAL OF CLINICAL INVESTIGATION, 1984, 74 (04) :1291-1300

[4]

ANTIBODY TO INTEGRIN ALPHA-6 SUBUNIT SPECIFICALLY INHIBITS CELL-BINDING TO LAMININ FRAGMENT-8 [J].

AUMAILLEY, M ;

TIMPL, R ;

SONNENBERG, A .

EXPERIMENTAL CELL RESEARCH, 1990, 188 (01) :55-60

[5]

TRANSFERRIN RECEPTOR AND ITS RECYCLING IN HELA-CELLS [J].

BLEIL, JD ;

BRETSCHER, MS .

EMBO JOURNAL, 1982, 1 (03) :351-355

[6]

ENDOCYTOSIS - RELATION TO CAPPING AND CELL LOCOMOTION [J].

BRETSCHER, MS .

SCIENCE, 1984, 224 (4650) :681-686

[7]

ENDOCYTOSIS AND RECYCLING OF THE FIBRONECTIN RECEPTOR IN CHO CELLS [J].

BRETSCHER, MS .

EMBO JOURNAL, 1989, 8 (05) :1341-1348

[8]

A NEW METHOD FOR DETECTING ENDOCYTOSED PROTEINS [J].

BRETSCHER, MS ;

LUTTER, R .

EMBO JOURNAL, 1988, 7 (13) :4087-4092

[9]

ALTERATIONS IN NEURAL CREST MIGRATION BY A MONOCLONAL-ANTIBODY THAT AFFECTS CELL-ADHESION [J].

BRONNERFRASER, M .

JOURNAL OF CELL BIOLOGY, 1985, 101 (02) :610-617

[10]

SELECTIVE-INHIBITION OF FIBRONECTIN-MEDIATED CELL-ADHESION BY MONOCLONAL-ANTIBODIES TO A CELL-SURFACE GLYCOPROTEIN [J].

BROWN, PJ ;

JULIANO, RL .

SCIENCE, 1985, 228 (4706) :1448-1451

← 1 2 3 4 5 →