ATRIAL-NATRIURETIC-FACTOR INHIBITS THE CRH-STIMULATED SECRETION OF ACTH AND CORTISOL IN MAN

被引:88
作者
KELLNER, M
WIEDEMANN, K
HOLSBOER, F
机构
[1] Max Planck Institute of Psychiatry, Clinical Institute, Dept. of Psychiatry, W-8000 Munich 40
关键词
D O I
10.1016/0024-3205(92)90543-X
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Corticotrophic secretion of ACTH is stimulated by corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP), and suppressed by glucocorticoids. In vitro and preclinical studies suggest that atrial natriuretic factor (ANF) may be a peptidergic inhibitor of pituitary-adrenocortical activity. The aim of this study was to elucidate a possible role of ANF as a modulator of ACTH release in humans. A bolus injection of 100-mu-g human CRH (hCRH) during a 30 min intravenous infusion of 5-mu-g/min human alpha atrial natriuretic factor (h-alpha-ANF) was administered at 19:00 to six healthy male volunteers. In comparison to saline, a blunted CRH-stimulated secretion of ACTH (mean maximum plasma level +/- SD 45 min after hCRH: saline 46.2 +/- 14.2 pg/ml, h-alpha-ANF 34.6 +/- 13.8 pg/ml, p-value = 0.007) and a delayed rise (10 min) in cortisol were detected. The maximum plasma cortisol levels remained nearly unchanged between saline and h-alpha-ANF administration (mean maximum plasma level +/- SD 60 min after hCRH: saline 182 +/- 26 ng/ml, h-alpha-ANF 166 +/- 54 ng/ml). No effects of h-alpha-ANF on basal cortisol levels were observed; in contrast, basal ACTH plasma levels were slightly reduced. Basal blood pressure and heart rate remained unaffected. In the control experiment, infusion of 3 IU AVP in the same experimental paradigm increased basal and stimulated ACTH and cortisol levels significantly in comparison to saline. These observations suggest that intravenously administered haANF inhibits the CRH-stimulated release of ACTH in man.
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页码:1835 / 1842
页数:8
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