INTERNATIONAL RENAL-CELL CANCER STUDY .1. TOBACCO USE

被引:250
作者
MCLAUGHLIN, JK
LINDBLAD, P
MELLEMGAARD, A
MCCREDIE, M
MANDEL, JS
SCHLEHOFER, B
POMMER, W
ADAMI, HO
机构
[1] NCI,DIV CANC ETIOL,EPIDEMIOL & BIOSTAT PROGRAM,BETHESDA,MD 20892
[2] UNIV UPPSALA HOSP,CANC EPIDEMIOL UNIT,S-75185 UPPSALA,SWEDEN
[3] DANISH CANC SOC,DANISH CANC REGISTRY,COPENHAGEN,DENMARK
[4] NEW S WALES CANC COUNCIL,CANC EPIDEMIOL RES UNIT,KINGS CROSS,AUSTRALIA
[5] UNIV MINNESOTA,SCH PUBL HLTH,DIV ENVIRONM HLTH,MINNEAPOLIS,MN 55455
[6] GERMAN CANC RES CTR,DIV EPIDEMIOL,W-6900 HEIDELBERG,GERMANY
[7] HUMBOLDT HOSP,BERLIN,GERMANY
关键词
D O I
10.1002/ijc.2910600211
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The relationship between renal-cell cancer (RCC) and tobacco use was investigated in an international, multicenter, population-based case-control study. Coordinated studies were conducted in Australia, Denmark, Germany, Sweden and the United States using a shared protocol and questionnaire. A total of 1,732 cases (1,050 men, 682 women) and 2,309 controls (1,429 men, 880 women) were interviewed for the study. No association was observed between risk and use of cigars, pipes or smokeless tobacco. A statistically significant association was observed for cigarette smoking, with current smokers having a 40% increase in risk [relative risk (RR)= 1.4, 95% confidence interval (CI) 1.2-1.7]. Risk increased with intensity (number of cigarettes) and duration (years smoked). Among current smokers the RR for pack-years rose from 1.1 (95% CI 0.8-1.5) for < 15.9 pack years to 2.0 (95% CI 1.6-2.7) for > 42 pack years (p for trend < 0.001). Long-term quitters (> 15 years) experienced a reduction in risk of about 15-25% relative to current smokers. Those who started smoking late (> 24 years of age) had about two-thirds the risk of those who started young (less than or equal to 12 years of age). Overall, the findings of this pooled analysis confirm that cigarette smoking is a causal factor in the etiology of RCC. (C) 1995 Wiley-Liss, Inc.(*)
引用
收藏
页码:194 / 198
页数:5
相关论文
共 35 条
[1]   RETROSPECTIVE STUDY OF RENAL CANCER WITH SPECIAL REFERENCE TO COFFEE AND ANIMAL PROTEIN CONSUMPTION [J].
ARMSTRONG, B ;
GARROD, A ;
DOLL, R .
BRITISH JOURNAL OF CANCER, 1976, 33 (02) :127-136
[2]  
ASAL NR, 1988, CANCER DETECT PREV, V11, P359
[3]   RISK-FACTORS FOR RENAL-CELL CARCINOMA IN A FRENCH CASE-CONTROL STUDY [J].
BENHAMOU, S ;
LENFANT, MH ;
ORYPAOLETTI, C ;
FLAMANT, R .
INTERNATIONAL JOURNAL OF CANCER, 1993, 55 (01) :32-36
[4]   VARIANCE CALCULATIONS AND CONFIDENCE-INTERVALS FOR ESTIMATES OF THE ATTRIBUTABLE RISK BASED ON LOGISTIC-MODELS [J].
BENICHOU, J ;
GAIL, MH .
BIOMETRICS, 1990, 46 (04) :991-1003
[5]  
BENNINGTON JL, 1968, CANCER-AM CANCER SOC, V21, P1069, DOI 10.1002/1097-0142(196806)21:6<1069::AID-CNCR2820210607>3.0.CO
[6]  
2-J
[7]  
BRESLOW NE, 1980, IARC SCI PUBLICAT 32, V1
[8]   A CASE-CONTROL STUDY OF RENAL-CELL CARCINOMA IN RELATION TO OCCUPATION, SMOKING, AND ALCOHOL-CONSUMPTION [J].
BROWNSON, RC .
ARCHIVES OF ENVIRONMENTAL HEALTH, 1988, 43 (03) :238-241
[9]   ESTIMATING THE POPULATION ATTRIBUTABLE RISK FOR MULTIPLE RISK-FACTORS USING CASE-CONTROL DATA [J].
BRUZZI, P ;
GREEN, SB ;
BYAR, DP ;
BRINTON, LA ;
SCHAIRER, C .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1985, 122 (05) :904-913
[10]  
GART JJ, 1970, BIOMETRIKA, V57, P471, DOI 10.2307/2334765