DECOMPLEMENTATION BY COBRA VENOM FACTOR SUPPRESSES YERSINIA-INDUCED ARTHRITIS IN RATS

被引：17

作者：

GAEDE, KI ^{[1
]}

BAUMEISTER, E ^{[1
]}

HEESEMANN, J ^{[1
]}

机构：

[1] UNIV WURZBURG, INST HYG & MICROBIOL, D-97080 WURZBURG, GERMANY

来源：

INFECTION AND IMMUNITY | 1995年 / 63卷 / 09期

关键词：

D O I：

10.1128/IAI.63.9.3697-3701.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lewis rats experimentally infected with Yersinia enterocolitica O8 develop Yersinia-induced arthritis (YIA), which resembles very much reactive arthritis in humans. To investigate the involvement of serum complement in induction and maintenance of YIA, we decomplementated Yersinia-infected Lewis rats by treatment with cobra venom factor starting on day 7 after infection (prearthritic state). Reduction of serum complement activity in vivo by cobra venom factor treatment coincided with suppression of YIA clinically and histomorphologically.

引用

页码：3697 / 3701

页数：5

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