IN-VIVO GENOTOXIC EFFECTS OF SMOKING AND OCCUPATIONAL LEAD-EXPOSURE IN PRINTING PRESS WORKERS

被引：15

作者：

RAJAH, T ^{[1
]}

AHUJA, YR ^{[1
]}

机构：

[1] UNIV OKLAHOMA, HLTH SCI CTR, COLL PHARM, OKLAHOMA CITY, OK 73190 USA

来源：

TOXICOLOGY LETTERS | 1995年 / 76卷 / 01期

关键词：

SISTER CHROMATID EXCHANGES; MITOTIC INDEX; SMOKING; OCCUPATIONAL EXPOSURE; LEAD;

D O I：

10.1016/0378-4274(94)03200-9

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The objective of the present study was to evaluate the genotoxicity of a combination exposure to lead and smoking in workers from the printing industry and also to examine the possible interaction between the two agents. Individuals were classified into 4 different groups: control group, lead-exposed group, smokers and the double-exposure group. Chromosomal analysis was carried out according to conventional methods. Our preliminary study shows that lead-exposed individuals had a significantly increased frequency of sister chromatid exchanges. Further, double exposure to smoking and lead inhibits mitosis.

引用

页码：71 / 75

页数：5

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