DIFFERENTIAL PATTERN OF ONCOGENE AND BETA-ACTIN EXPRESSION IN LEUKEMIC-CELLS FROM AML PATIENTS

被引：14

作者：

BLOMBERG, J ^{[1
]}

ANDERSSON, M ^{[1
]}

FALDT, R ^{[1
]}

机构：

[1] UNIV LUND, DEPT INTERNAL MED, S-22362 LUND, SWEDEN

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1987年 / 65卷 / 01期

关键词：

D O I：

10.1111/j.1365-2141.1987.tb06139.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The presence of mRNA hybridizing to five oncogene (fos, mos, myc, sis, abl) and a beta-actin probe(s) was studied with a sesmiquantitative dot-blot procedure in eight AML patients. Around 107 leucocytes, corresponding to 1-10 ml blood, sufficed for the analysis. Each patient, regardless of the FAB group, exhibited a distinct pattern of oncogene or beta-actin expression. Especially strong signals were obtained with the beta-actin probe in two patients and with the fos probe in three patients. The findings underscore the heterogeneity of AML, either present from the first step towards malignancy or arising during the progression of the disease. The pattern of oncogene expression in leukaemic cells studied in routine blood samples may become an additional means for classification and follow-up of AML patients.

引用

页码：83 / 86

页数：4

共 12 条

[1]

ALITALO K, 1985, LANCET, V2, P1035

[2]

BLICK M, 1984, BLOOD, V64, P1234

[3] AMINO-ACID SUBSTITUTIONS AT CODON-13 OF THE N-RAS ONCOGENE IN HUMAN ACUTE MYELOID-LEUKEMIA [J].