PROTRACTED ALANINE AMINOTRANSFERASE LEVELS IN TAMARINS INFECTED WITH HEPATITIS-A VIRUS

被引:8
作者
KARAYIANNIS, P
CHITRANUKROH, R
FRY, M
PETROVIC, LM
MOORE, D
SCHEUER, PJ
THOMAS, HC
机构
[1] ROYAL FREE HOSP,DEPT MED,LONDON,ENGLAND
[2] ROYAL FREE HOSP,DEPT HISTOPATHOL,LONDON,ENGLAND
[3] ROYAL FREE HOSP,COMPARAT BIOL UNIT,LONDON,ENGLAND
关键词
ALT; IgM anti‐HAV;
D O I
10.1002/jmv.1890300214
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Eighteen red‐bellied tamarins (Saguinus labiatus), experimentally infected with hepatitis A virus (HAV), were followed for up to 1.5 years after initial challenge. Half of these animals developed protracted alanine aminotransferase (ALT) abnormalities, which lasted for between 23 and 55 weeks post‐challenge. IgM anti‐HAV was detected intermittently during the early phase of their relapsing hepatitis and never after return of ALT levels to normal. The possibility that these findings may be related to continued HAV replication, coinfection with another agent, or the result of an autoimmune phenomenon triggered by HAV are discussed. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码:151 / 158
页数:8
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