RECOGNITION OF A PEPTIDE ANTIGEN BY HEAT-SHOCK REACTIVE GAMMA-DELTA-LYMPHOCYTES-T

被引：307

作者：

BORN, W

HALL, L

DALLAS, A

BOYMEL, J

SHINNICK, T

YOUNG, D

BRENNAN, P

OBRIEN, R

机构：

[1] NATL JEWISH CTR IMMUNOL & RESP MED,DEPT MED,DENVER,CO 80206

[2] COLORADO STATE UNIV,DEPT MICROBIOL,FT COLLINS,CO 80523

[3] CTR DIS CONTROL,DIV BACTERIAL DIS,ATLANTA,GA 30333

[4] HAMMERSMITH HOSP,MRC,TB & RELATED INFECT UNIT,LONDON W12 0HS,ENGLAND

来源：

SCIENCE | 1990年 / 249卷 / 4964期

关键词：

D O I：

10.1126/science.1695022

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Small synthetic peptides that correspond to different portions of the 65-kilodalton mycobacterial heat shock protein (Hsp65) were used to identify a putative antigenic epitope for γδ cells. Weaker γδ responses to the equivalent portion of the autologous homolog, mouse Hsp63, were also seen. The stimulatory epitope overlaps with an epitope recognized by arthritogenic αβ T cell clones. The data suggest that γδ cells have a role in autoimmune disorders and imply that these cells recognize ligands by a mechanism similar to that of γδ T lymphocytes, that is, in the form of small processed protein fragments bound to antigen-presenting molecules.

引用

页码：67 / 69

页数：3

共 36 条

[1] LIMITED DIVERSITY OF GAMMA-DELTA-ANTIGEN RECEPTOR GENES OF THY-1+ DENDRITIC EPIDERMAL-CELLS [J].