POSTNATAL-DEVELOPMENT OF VOLTAGE-DEPENDENT CALCIUM CHANNELS IN THE MOUSE-BRAIN DISCLOSED BY THE XENOPUS OOCYTE ASSAY

被引：4

作者：

COHEN, RW ^{[1
]}

CAMPAGNONI, AT ^{[1
]}

HULL, CD ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,CTR HLTH SCI,MENTAL RETARDAT RES CTR,760 WESTWOOD PLAZA,LOS ANGELES,CA 90024

来源：

DEVELOPMENTAL NEUROSCIENCE | 1990年 / 12卷 / 02期

关键词：

Calcium channels; Development; Mouse; Serotonin; Verapamil; Xenopus oocyte assay;

D O I：

10.1159/000111837

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We assessed the ontogeny of murine voltage-dependent calcium channels by extracting mRNA from brains of mice at different postnatal ages and injecting the mRNA into oocytes of the frog, Xenopus laevis. Voltage-dependent Ca2+-activated Cl- channels were measured to assess the presence of Ca2+ channels. When compared with water-injected oocytes (controls), an increase in Ca2+ channels was not detected until postnatal day 7. The number of Ca2+ channels peaked between 9 and 18 days and began to decline by 35 days. Bath application of barium, serotonin and the Ca2+ channel antagonist, verapamil, to mRNA-injected oocytes confirmed the presence of Ca2+ channels.

引用

页码：81 / 88

页数：8

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