RELATIONSHIP BETWEEN INTESTINAL PERMEABILITY TO [CR-51] EDTA AND INFLAMMATORY ACTIVITY IN ASYMPTOMATIC PATIENTS WITH CROHNS-DISEASE

The relationship between intestinal permeability to an oral dose (100 μCi) of [51CR]EDTA and the inflammatory activity of Crohn's disease was studied in 63 adult patients (32 unresected and 31 resected) who underwent 162 evaluations. The results of the [51CR]EDTA test were compared with the serum levels of the acute-phase reactant proteins (APRP) and with the result of the [111In]leukocyte scanning, respectively, as an indirect and direct method to assess intestinal inflammation. In a group of healthy adult controls, the upper normal value for the 24-hr urinary [51CR]EDTA excretion was 3.61 (97.5 percentile) and the mean coefficient of variation was 21%. Sensitivity and specificity of the [51CR]EDTA test in identifying active inflammation expressed by increased serum levels of APRP were, respectively, 97% and 54% in the unresected group and 68% and 52% in the resected group of patients. The low specificity of the test was due to the presence of increased [51CR]EDTA urinary excretion in about half the cases with normal serum levels of APRP. The [111In] leukocyte scanning was performed in a subgroup of 11 patients (three unresected and eight resected) with normal serum levels of APRP, six with increased and five with normal [51CR]EDTA urinary excretion. All six patients with increased intestinal permeability had a positive111In image of mild to moderate degree of activity. A positive111In scan was present in two of the five patients with normal permeability; these were two resected patients. We conclude that in patients with Crohn's disease in remission, increased [51CR]EDTA urinary excretion can be considered an indirect sign of active inflammation, with a sensitivity greater than the serum levels of the APRP for the presence of intestinal areas of inflammation of mild to moderate degree. © 1990 Plenum Publishing Corporation.