ENANTIOMERIC SEPARATION OF 2-CHLOROPROPIONIC ACID BY ENZYMATIC ESTERIFICATION IN ORGANIC-SOLVENTS

被引：20

作者：

BODNAR, J

GUBICZA, L

SZABO, LP

机构：

[1] Research Institute for Technical Chemistry, the Hungarian Academy of Sciences

来源：

JOURNAL OF MOLECULAR CATALYSIS | 1990年 / 61卷 / 03期

关键词：

D O I：

10.1016/0304-5102(90)80008-7

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The kinetic resolution of 2-chloro-propionic acid by enzyme catalyzed esterification in different organic solvents has been studied. The rate and enantioselectivity of the reaction catalyzed by yeast (Canadida cylindracea) lipase were determined under various reaction conditions. The effect of several reaction parameters, such as solvent polarity, water content of the reaction mixture, the nature of the nucleophilic agent, the molar ratio of the substrates and the reaction temperature, are discussed. © 1990.

引用

页码：353 / 361

页数：9

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