SPECIFIC ANTI-HIV-1 ACYCLONUCLEOSIDES WHICH CANNOT BE PHOSPHORYLATED - SYNTHESIS OF SOME DEOXY ANALOGS OF 1-[(2-HYDROXYETHOXY)METHYL]-6-(PHENYLTHIO)THYMINE

被引:80
作者
TANAKA, H
BABA, M
SAITO, S
MIYASAKA, T
TAKASHIMA, H
SEKIYA, K
UBASAWA, M
NITTA, I
WALKER, RT
NAKASHIMA, H
DECLERCQ, E
机构
[1] SHOWA UNIV,SCH PHARMACEUT SCI,HATANODAI 1-5-8,SHINAGAWA KU,TOKYO 142,JAPAN
[2] MITSUBISHI KASEI CORP,RES CTR,YOKOHAMA 227,JAPAN
[3] UNIV BIRMINGHAM,DEPT CHEM,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND
[4] CATHOLIC UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM
关键词
D O I
10.1021/jm00108a041
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:1508 / 1511
页数:4
相关论文
共 23 条
[1]   SYNTHESIS OF PYRIMIDINE ACYCLONUCLEOSIDES [J].
ABRAMS, HM ;
HO, L ;
CHU, SH .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1981, 18 (05) :947-951
[2]   HIGHLY SPECIFIC-INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 BY A NOVEL 6-SUBSTITUTED ACYCLOURIDINE DERIVATIVE [J].
BABA, M ;
TANAKA, H ;
DECLERCQ, E ;
PAUWELS, R ;
BALZARINI, J ;
SCHOLS, D ;
NAKASHIMA, H ;
PERNO, CF ;
WALKER, RT ;
MIYASAKA, T .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (03) :1375-1381
[3]  
BABA M, 1991, IN PRESS P NATL ACAD
[4]   THE EFFICACY OF AZIDOTHYMIDINE (AZT) IN THE TREATMENT OF PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].
FISCHL, MA ;
RICHMAN, DD ;
GRIECO, MH ;
GOTTLIEB, MS ;
VOLBERDING, PA ;
LASKIN, OL ;
LEEDOM, JM ;
GROOPMAN, JE ;
MILDVAN, D ;
SCHOOLEY, RT ;
JACKSON, GG ;
DURACK, DT ;
KING, D .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (04) :185-191
[5]   PREPARATION OF 8-CHLOROPURINE NUCLEOSIDES THROUGH THE REACTION BETWEEN THEIR C-8 LITHIATED SPECIES AND PARA-TOLUENESULFONYL CHLORIDE [J].
HAYAKAWA, H ;
TANAKA, H ;
HARAGUCHI, K ;
MAYUMI, M ;
NAKAJIMA, M ;
SAKAMAKI, T ;
MIYASAKA, T .
NUCLEOSIDES & NUCLEOTIDES, 1988, 7 (01) :121-128
[6]  
HAYAKAWA H, 1987, CHEM PHARM BULL, V35, P72
[7]   A LITHIATION APPROACH TO CORDYCEPIN ANALOGS VARIOUSLY SUBSTITUTED AT THE C-8 POSITION [J].
HAYAKAWA, H ;
TANAKA, H ;
SASAKI, K ;
HARAGUCHI, K ;
SAITOH, T ;
TAKAI, F ;
MIYASAKA, T .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1989, 26 (01) :189-192
[8]   HIV WITH REDUCED SENSITIVITY TO ZIDOVUDINE (AZT) ISOLATED DURING PROLONGED THERAPY [J].
LARDER, BA ;
DARBY, G ;
RICHMAN, DD .
SCIENCE, 1989, 243 (4899) :1731-1734
[9]   A NOVEL LEAD FOR SPECIFIC ANTI-HIV-1 AGENTS - 1-[(2-HYDROXYETHOXY)METHYL]-6-(PHENYLTHIO)THYMINE [J].
MIYASAKA, T ;
TANAKA, H ;
BABA, M ;
HAYAKAWA, H ;
WALKER, RT ;
BALZARINI, J ;
DECLERCQ, E .
JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (12) :2507-2509
[10]   POTENT AND SELECTIVE-INHIBITION OF HIV-1 REPLICATION INVITRO BY A NOVEL SERIES OF TIBO DERIVATIVES [J].
PAUWELS, R ;
ANDRIES, K ;
DESMYTER, J ;
SCHOLS, D ;
KUKLA, MJ ;
BRESLIN, HJ ;
RAEYMAECKERS, A ;
VANGELDER, J ;
WOESTENBORGHS, R ;
HEYKANTS, J ;
SCHELLEKENS, K ;
JANSSEN, MAC ;
DECLERCQ, E ;
JANSSEN, PAJ .
NATURE, 1990, 343 (6257) :470-474