ARCHITECTURE AND DESIGN OF THE NUCLEAR-PORE COMPLEX

被引:373
作者
HINSHAW, JE [1 ]
CARRAGHER, BO [1 ]
MILLIGAN, RA [1 ]
机构
[1] UNIV CALIF SAN DIEGO, LA JOLLA, CA 92093 USA
关键词
D O I
10.1016/0092-8674(92)90635-P
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A three-dimensional analysis of the nuclear pore complex reveals the underlying, highly symmetric framework of this supramolecular assembly, how it is anchored in the nuclear membrane, and how it is built from many distinct, interconnected subunits. The arrangement of the subunits within the membrane pore creates a large central channel, through which active nucleocytoplasmic transport is known to occur, and eight smaller peripheral channels that are probable routes for passive diffusion of ions and small molecules.
引用
收藏
页码:1133 / 1141
页数:9
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