HEMODYNAMIC-EFFECTS OF COMBINED TREATMENT WITH SOMATOSTATIN ANALOG (SMS-201-995) AND LOW-DOSE ISOSORBIDE DINITRATE ON PORTAL-HYPERTENSION IN CONSCIOUS CIRRHOTIC RATS

被引：12

作者：

HORI, N ^{[1
]}

OKANOUE, T ^{[1
]}

SAWA, Y ^{[1
]}

ITOH, Y ^{[1
]}

MORI, T ^{[1
]}

TAKAMI, S ^{[1
]}

KASHIMA, K ^{[1
]}

机构：

[1] KYOTO PREFECTURAL UNIV MED,DEPT INTERNAL MED 3,KAWARAMACHI HIROKOJI KAMIGYO KU,KYOTO 602,JAPAN

来源：

JOURNAL OF GASTROENTEROLOGY | 1994年 / 29卷 / 04期

关键词：

SOMATOSTATIN ANALOG (SMS-201-995); ISOSORBIDE DINITRATE; COMBINATION THERAPY; PORTAL HYPERTENSION; RADIOACTIVE MICROSPHERE METHOD;

D O I：

10.1007/BF02361244

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The authors investigated whether combined treatment with the somatostatin analogue, SMS 201-995, and low-dose isosorbide dinitrate enhanced the hemodynamic effects of the individual agents on rats with thioacetamide-induced cirrhosis. Four groups of cirrhotic rats received SMS 201-995 (0.1 mug.min-1.kg-1), isosorbide dinitrate (10 mug.min-1.kg-1), both agents, or placebo, respectively. Hemodynamics were measured serially in conscious rats, using a radioactive microsphere method. SMS 201-995 reduced portal venous inflow 21 +/- 4% and portal pressure 17 +/- 3%. Isosorbide dinitrate decreased portal venous inflow 20 +/- 4%, by inducing splanchnic vasoconstriction mediated by low pressure baroreflexes, and this agent also decreased portal pressure, by 14 +/- 2%. Portal venous resistance rose 7.6 +/- 3% with isosorbide dinitrate alone, but decreased 18 +/- 4% with combination therapy. This effect may have been induced by the pronounced vasodilatory effect of isosorbide dinitrate on the venous vasculature, since the reflex splanchnic vasoconstriction that occurs with low-dose isosorbide dinitrate disappears when this agent is combined with SMS 201-995. The decrease in portal pressure was more marked (22 +/- 4%) and changes in systemic hemodynamics were milder with the combined treatment. It was concluded that combination therapy with SMS 201-995 and low-dose isosorbide dinitrate may be beneficial for portal hypertension in liver cirrhosis.

引用

页码：460 / 468

页数：9

共 37 条

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