BDNF ATTENUATES THE EFFECTS OF INTRASTRIATAL INJECTION OF 6-HYDROXYDOPAMINE

被引：85

作者：

SHULTS, CW

KIMBER, T

ALTAR, CA

机构：

[1] UNIV CALIF SAN DIEGO,DEPT NEUROSCI,LA JOLLA,CA 92093

[2] REGENERON PHARMACEUT INC,TARRYTOWN,NY 10591

来源：

NEUROREPORT | 1995年 / 6卷 / 08期

关键词：

BRAIN-DERIVED NEUROTROPHIC FACTOR; PARKINSONS DISEASE; 6-HYDROXYDOPAMINE; STRIATUM; DOPAMINE; SUBSTANTIA NIGRA; NEUROPROTECTION; NEUROTROPHIN;

D O I：

10.1097/00001756-199505300-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GROUPS of eight rats received unilateral, intrastriatal injections of 22.5 mu g brain-derived neurotrophic factor (BDNF)or cytochrome c on 3 consecutive days. Following the injection of BDNF or cytochrome c on the second day, each animal received an intrastriatal injection of 25 mu g of C-hydroxydopamine (6-OHDA). During the second week following treatment and thereafter, the animals that received BDNF had significantly fewer apomorphine-induced, contraversive rotations than did the animals that received cytochrome c. The animals that received BDNF but not those that received cytochrome c had a halo of dopaminergic axons around the injection site. Our data indicate that BDNF can attenuate the loss of dopaminergic axons and rotational asymmetry that result from an intrastriatal injection of 6-OHDA.

引用

页码：1109 / 1112

页数：4

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