FLUORESCENT HUMIC SUBSTANCES AND BLACKFOOT DISEASE IN TAIWAN - REVIEW

被引：52

作者：

LU, FJ

机构：

[1] Department of Biochemistry, College of Medicine, National Taiwan University, Taipei

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 1990年 / 4卷 / 03期

关键词：

arsenic; Blackfoot disease; fluorescent humic substances; Taiwan;

D O I：

10.1002/aoc.590040304

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Blackfoot disease is endemic in Chia Yi and Tainan Counties in south‐western Taiwan. Arsenic present in the drinking water taken from wells has been blamed for causing this disease. The discovery in 1975 of fluorescent compounds in these well waters led to the isolation of these substances, to their identification as humic substances containing a large number of elements (among them arsenic), and to the development of an animal model for blackfoot disease. Mice receiving aqueous solutions of these fluorescent substances at a daily dose of 5 mg per 20 g body mass for at least 22 days developed blackfoot and blacktail disease. Work with these fluorescent substances, their chemical properties, and their biological actions is reviewed. Copyright © 1990 John Wiley & Sons Ltd.

引用

页码：191 / 195

页数：5

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