THE EFFECT OF ACUTE HYPERTENSION ON BLOOD-BRAIN-BARRIER PERMEABILITY TO ALBUMIN DURING EXPERIMENTALLY INDUCED EPILEPTIC SEIZURES

被引：29

作者：

OZTAS, B

KAYA, M

机构：

[1] Department of Physiology, Istanbul Faculty of Medicine, University of Istanbul, Çapa

来源：

PHARMACOLOGICAL RESEARCH | 1991年 / 23卷 / 01期

关键词：

BLOOD-BRAIN BARRIER; EVANS BLUE; SEIZURE;

D O I：

10.1016/S1043-6618(05)80104-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study was to examine the effect on the blood-brain barrier function of a rapid blood pressure elevation and the duration of this pressure during bicuculline and pentylenetetrazol-induced seizures. The experiments were carried out on Wistar rats. Evans blue was used as a blood-brain barrier tracer. Our results showed that the presence of blood pressure increase does not always result in blood-brain barrier leakage during convulsions. Besides the rate of increase in the pressure, the duration of this increased pressure was the important factor in the disruption of blood-brain barrier during bicuculline or pentylenetetrazol-induced seizures. © 1991 The Italian Pharmacological Society.

引用

页码：41 / 46

页数：6

共 18 条

[1]

[Anonymous], 1979, CONCEPT BLOOD BRAIN

[2]

BOLWIG TG, 1977, ACTA NEUROL SCAND, V56, P335

[3] BICUCULLINE, AN ANTAGONIST OF GABA AND SYNAPTIC INHIBITION IN SPINAL CORD OF CAT [J].