EVIDENCE FOR THE GENERATION OF HYDROXYL RADICALS FROM A CHROMIUM(V) INTERMEDIATE ISOLATED FROM THE REACTION OF CHROMATE WITH GLUTATHIONE

被引：57

作者：

JONES, P ^{[1
]}

KORTENKAMP, A ^{[1
]}

OBRIEN, P ^{[1
]}

WANG, GF ^{[1
]}

YANG, G ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT CHEM,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1991年 / 286卷 / 02期

关键词：

D O I：

10.1016/0003-9861(91)90095-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The formation of hydroxyl radicals from a chromium(V) complex isolated from the reaction of glutathione with chromate has been demonstrated in spin trapping experiments using dimethylsulfoxide and 3,5-dibromo-4-nitrosobenzene sulfonate. Mechanisms for the formation of radicals in such systems are discussed. These results help to explain the ability of solutions containing chromate and glutathione to cause strand breaks in DNA. © 1991.

引用

页码：652 / 655

页数：4

共 30 条

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