PROTECTION OF GUINEA-PIGS AGAINST FOOT-AND-MOUTH-DISEASE VIRUS BY IMMUNIZATION WITH A PHOE FMDV HYBRID PROTEIN

被引：13

作者：

AGTERBERG, M

ADRIAANSE, H

BARTELING, S

VANMAANEN, K

TOMMASSEN, J

机构：

[1] STATE UNIV UTRECHT,INST MOLEC BIOL & MED BIOTECHNOL,PADUALAAN 8,3584 CH UTRECHT,NETHERLANDS

[2] CENT VET INST,8221 RA LELYSTAD,NETHERLANDS

[3] STATE UNIV UTRECHT,DEPT MOLEC CELL BIOL,3584 CH UTRECHT,NETHERLANDS

来源：

VACCINE | 1990年 / 8卷 / 05期

关键词：

carrier system; foot-and-mouth disease virus; PhoE protein; vaccine;

D O I：

10.1016/0264-410X(90)90242-E

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A hybrid protein was constructed containing two antigenic determinants of the structural protein VPI of foot-and-mouth disease virus, inserted in a cell surface-exposed region of Escherichia coli outer membrane protein PhoE. Immunization of guinea-pigs with partially purified protein resulted in high levels of neutralizing antibodies and complete protection against challenge with the virus. © 1990.

引用

页码：438 / 440

页数：3

共 20 条

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