EFFECTS OF HYDROQUINONES ON INTACT TRYPANOSOMA-CRUZI EPIMASTIGOTES

被引:18
作者
ALDUNATE, J
TRAIPE, L
SPENCER, P
MORELLO, A
REPETTO, Y
机构
[1] Department of Biochemistry, Faculty of Medicine, University of Chile, Santiago, 7
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1992年 / 103卷 / 01期
关键词
D O I
10.1016/0742-8413(92)90234-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
1. Hydroquinones inhibited the culture growth of Trypanosoma cruzi epimastigotes at concentrations lower than 1 mM. 2. Hydroquinones inhibited the oxygen consumption on the intact Trypanosoma cruzi cells. I50 values for hydroquinone, terbutylhydroquinone and 2,5-di-t-butylhydroquinone were 24.87 mM, 0.88 mM and 0.26 mM, respectively. t-Butylhydroquinone and 2,5-di-t-butylhydroquinone had a Michaelian type kinetic inhibition: hydroquinone also showed a Michaelian type kinetic inhibition at low concentrations but at higher concentrations it showed a positive cooperativity. 3. These hydroquinones changed the NAD(P) redox-state to a more reduced state and that of cytochrome b to a more oxidized state. The magnitude of the redox-state change was dependent of the hydrofobicity of the derivates. 4. These results suggest that the growth and oxygen uptake inhibition by the hydroquinones is due to a blockage of the mitochondrial electron transport chain before cytochrome b.
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页码:97 / 100
页数:4
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