INDUCTION OF PROTECTIVE CYTOTOXIC T-CELLS TO MURINE CYTOMEGALOVIRUS BY USING A NONAPEPTIDE AND A HUMAN-COMPATIBLE ADJUVANT (MONTANIDE ISA-720)

被引：57

作者：

SCALZO, AA

ELLIOTT, SL

COX, J

GARDNER, J

MOSS, DJ

SUHRBIER, A

机构：

[1] QUEENSLAND INST MED RES, BANCROFT CTR, BRISBANE, QLD 4029, AUSTRALIA

[2] UNIV WESTERN AUSTRALIA, QUEEN ELIZABETH II MED CTR, DEPT MICROBIOL, NEDLANDS, WA 6009, AUSTRALIA

[3] COMMONWEALTH SERUM LABS, RES & DEV SECT, MELBOURNE, VIC 3052, AUSTRALIA

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 02期

关键词：

D O I：

10.1128/JVI.69.2.1306-1309.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The use of synthetic peptides representing cytotoxic T-cell (CTL) epitopes for human vaccination requires the identification of a suitable adjuvant formulation. A single immunization,vith Montanide ISA720/tetanus toxoid/YPHFMPTNL protected mice against murine cytomegalovirus and induced epitope-specific CTL. Such formulations will find application in peptide-based CTL anti-viral vaccines.

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页码：1306 / 1309

页数：4

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