SYNTHESIS OF THIAZOLE-4-CARBOXAMIDE ADENINE-DINUCLEOTIDE - A POWERFUL INHIBITOR OF IMP DEHYDROGENASE

被引：47

作者：

GEBEYEHU, G ^{[1
]}

MARQUEZ, VE ^{[1
]}

KELLEY, JA ^{[1
]}

COONEY, DA ^{[1
]}

JAYARAM, HN ^{[1
]}

JOHNS, DG ^{[1
]}

机构：

[1] NCI, DIV CANC TREATMENT, PROGRAM DEV THERAPEUT, MED CHEM & BIOL LAB, BETHESDA, MD 20205 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1983年 / 26卷 / 06期

关键词：

D O I：

10.1021/jm00360a025

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：922 / 925

页数：4

共 14 条

[1] P-31 AND C-13 NUCLEAR MAGNETIC-RESONANCE STUDIES OF NICOTINAMIDE-ADENINE DINUCLEOTIDE AND RELATED COMPOUNDS [J].

BLUMENSTEIN, M ;

RAFTERY, MA .

BIOCHEMISTRY, 1972, 11 (09) :1643-+

[2] THE CONVERSION OF 2-BETA-D-RIBOFURANOSYLTHIAZOLE-4-CARBOXAMIDE TO AN ANALOG OF NAD WITH POTENT IMP DEHYDROGENASE-INHIBITORY PROPERTIES [J].

COONEY, DA ;

JAYARAM, HN ;

GEBEYEHU, G ;

BETTS, CR ;

KELLEY, JA ;

MARQUEZ, VE ;

JOHNS, DG .

BIOCHEMICAL PHARMACOLOGY, 1982, 31 (11) :2133-2136

[3]

COONEY DA, ADV ENZ REG

[4]

DAWSON WH, 1977, J CARB-NUCLEOS-NUCL, V4, P363

[5] P-31 NMR-STUDIES OF NADPH AND NADP+ BINDING TO L-CASEI DIHYDROFOLATE-REDUCTASE [J].

FEENEY, J ;

BIRDSALL, B ;

ROBERTS, GCK ;

BURGEN, ASV .

NATURE, 1975, 257 (5527) :564-566

[6] SYNTHESIS OF C-GLYCOSYL THIAZOLES [J].

FUERTES, M ;

GARCIALOPEZ, T ;

GARCIAMUNOZ, G ;

STUD, M .

JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (26) :4074-4077

[7] STUDIES ON PYROPHOSPHATES .3. NEW METHOD FOR SYNTHESIS OF NUCLEOTIDE COENZYMES BY MEANS OF DI-N-BUTYLPHOSPHINOTHIOYL BROMIDE [J].

FURUSAWA, K ;

SEKINE, M ;

HATA, T .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (16) :1711-1716

[8] CODEHYDROGENASES .3. A SYNTHESIS OF DIPHOSPHOPYRIDINE NUCLEOTIDE (COZYMASE), AND SOME OBSERVATIONS ON THE SYNTHESIS OF TRIPHOSPHOPYRIDINE NUCLEOTIDE [J].

HUGHES, NA ;

KENNER, GW ;

TODD, A .

JOURNAL OF THE CHEMICAL SOCIETY, 1957, (AUG) :3733-3738

[9] STUDIES ON THE MECHANISM OF ACTION OF 2-BETA-D-RIBOFURANOSYLTHIAZOLE-4-CARBOXAMIDE (NSC 286193) .2. RELATIONSHIP BETWEEN DOSE LEVEL AND BIOCHEMICAL EFFECTS IN P388 LEUKEMIA INVIVO [J].

JAYARAM, HN ;

SMITH, AL ;

GLAZER, RI ;

JOHNS, DG ;

COONEY, DA .

BIOCHEMICAL PHARMACOLOGY, 1982, 31 (23) :3839-3845

[10] MECHANISM OF RESISTANCE TO THE ONCOLYTIC C-NUCLEOSIDE 2-BETA-D-RIBOFURANOSYLTHIAZOLE-4-CARBOXAMIDE (NSC-286193) [J].

JAYARAM, HN ;

COONEY, DA ;

GLAZER, RI ;

DION, RL ;

JOHNS, DG .

BIOCHEMICAL PHARMACOLOGY, 1982, 31 (15) :2557-2560

← 1 2 →