INTERLEUKIN-2 SUPPRESSES ESTABLISHED LONG-TERM POTENTIATION AND INHIBITS ITS INDUCTION IN THE RAT HIPPOCAMPUS

被引：117

作者：

TANCREDI, V

ZONA, C

VELOTTI, F

EUSEBI, F

SANTONI, A

机构：

[1] UNIV ROME LA SAPIENZA,DIPARTIMENTO MED SPERIMENTALE,I-00185 ROME,ITALY

[2] UNIV LAQUILA,DEPT MED SPERIMENTALE,I-67100 LAQUILA,ITALY

来源：

BRAIN RESEARCH | 1990年 / 525卷 / 01期

关键词：

Hippocampal slice; Interleukin-2; Long-term potentiation;

D O I：

10.1016/0006-8993(90)91331-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of recombinant interleukin-2 (rIL-2) on teh potentiation of thesynaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation LTP) in a dose-dependent manner. In addition, rIL-2 (1000 U/ml) reduced both post-tetanic potentiation (PTP) and LTP maintenance phase. The possible involvement of rIL-2 action on the synaptic potentiation with the enzymatic activity of protein kinase systems is discussed. © 1990.

引用

页码：149 / 151

页数：3

共 18 条

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