OFF-VERTICAL AXIS ROTATIONAL RESPONSES IN PATIENTS WITH UNILATERAL PERIPHERAL VESTIBULAR LESIONS

被引:35
作者
FURMAN, JMR
SCHOR, RH
KAMERER, DB
机构
[1] Department of Otolaryngology, Eye and Ear Institute of Pittsburgh, Pittsburgh, Pennsylvania
关键词
ACOUSTIC NEUROMA; OTOLITH ORGANS; VESTIBULOOCULAR REFLEX;
D O I
10.1177/000348949310200211
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Off-vertical axis rotation (OVAR) stimulates the otolith organs in a manner that is suitable for assessment of the otolith-ocular reflex. To further assess the potential clinical usefulness of OVAR, the eye movement responses of seven patients with surgically confirmed unilateral peripheral vestibular lesions were compared with the eye movement responses of a group of age-matched, healthy, asymptomatic control subjects. Patients and controls were tested with constant velocity rotations that followed a brief period of angular acceleration (velocity trapezoid) using either earth-vertical axis (EVA) rotation or OVAR. Both EVA and OVAR sinusoidal velocity profiles were also performed. Results indicated that each patient had 1) an asymmetric OVAR response, ie, a bias component whose direction was opposite normal when rotating toward the lesioned ear, and 2) a normal modulation component. Population data suggested that patients had 1) a more rapid decay of response than normal subjects during OVAR velocity trapezoids, 2) an increased phase lead as compared to normal subjects during sinusoidal OVAR, and 3) like normal subjects, a less rapid decay of response during OVAR velocity trapezoids than during EVA rotational velocity trapezoids. Taken together, these findings suggest that patients with unilateral peripheral vestibular deficits have abnormal otolith-ocular and semicircular canal-ocular reflexes but that a single labyrinth appears to provide an otolithic signal sufficient for qualitatively normal semicircular canal-otolith interaction.
引用
收藏
页码:137 / 143
页数:7
相关论文
共 17 条
[1]   CHANGES IN THE HUMAN VESTIBULO-OCULAR REFLEX AFTER LOSS OF PERIPHERAL SENSITIVITY [J].
BALOH, RW ;
HONRUBIA, V ;
YEE, RD ;
HESS, K .
ANNALS OF NEUROLOGY, 1984, 16 (02) :222-228
[2]  
BENSON AJ, 1966, AEROSPACE MED, V37, P889
[3]  
BENSON AJ, 1970, 5TH S ROL VEST ORG S, P221
[4]  
BLAKLEY BW, 1989, J OTOLARYNGOL, V18, P210
[5]   EYE-MOVEMENTS INDUCED BY OFF-VERTICAL AXIS ROTATION (OVAR) AT SMALL ANGLES OF TILT [J].
DARLOT, C ;
DENISE, P ;
DROULEZ, J ;
COHEN, B ;
BERTHOZ, A .
EXPERIMENTAL BRAIN RESEARCH, 1988, 73 (01) :91-105
[6]  
DENISE P, 1986, THESIS U PARIS PARIS
[7]  
FUJINO A, 1991, ACTA OTO-LARYNGOL, P67
[8]   OFF-VERTICAL AXIS ROTATION - A TEST OF THE OTOLITH-OCULAR REFLEX [J].
FURMAN, JMR ;
SCHOR, RH ;
SCHUMANN, TL .
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 1992, 101 (08) :643-650
[9]   EARTH HORIZONTAL AXIS ROTATIONAL RESPONSES IN PATIENTS WITH UNILATERAL PERIPHERAL VESTIBULAR DEFICITS [J].
FURMAN, JMR ;
WALL, C ;
KAMERER, DB .
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 1989, 98 (07) :551-555
[10]   A MODEL OF THE NYSTAGMUS INDUCED BY OFF VERTICAL AXIS ROTATION [J].
HAIN, TC .
BIOLOGICAL CYBERNETICS, 1986, 54 (4-5) :337-350