THE EFFECT OF AGING AND ACETYL-L-CARNITINE ON THE ACTIVITY OF THE PHOSPHATE CARRIER AND ON THE PHOSPHOLIPID-COMPOSITION IN RAT-HEART MITOCHONDRIA

被引：102

作者：

PARADIES, G ^{[1
]}

RUGGIERO, FM ^{[1
]}

GADALETA, MN ^{[1
]}

QUAGLIARIELLO, E ^{[1
]}

机构：

[1] UNIV BARI,CNR,STUDY MITOCHONDRIA & BIOENERGET UNIT,I-70124 BARI,ITALY

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1103卷 / 02期

关键词：

MITOCHONDRION; PHOSPHATE CARRIER; PHOSPHOLIPID; AGING; ACETYL-L-CARNITINE;

D O I：

10.1016/0005-2736(92)90103-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of aging and treatment with acetyl-L-carnitine on the activity of the phosphate carrier and on the phospholipid composition in rat heart mitochondria was studied. It was found that the activity of the phosphate carrier was reduced by aging. Treatment of aged rats with acetyl-L-carnitine reversed this effect. The mitochondrial level of cardiolipin was decreased with aging. Treatment of aged rats with acetyl-L-carnitine restored the level of cardiolipin to that of young rats. It is proposed that acetyl-L-carnitine may restore the correct phospholipid composition (cardiolipin level) of the mitochondrial membrane, altered by aging, thereby restoring the activity of the phosphate carrier.

引用

页码：324 / 326

页数：3

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