APPLICATION OF THE EXTENDED HILDEBRAND SOLUBILITY PARAMETER TREATMENT FOR OPTIMIZING REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY DETERMINATION OF PHARMACEUTICALS

被引：4

作者：

GONZALEZ, AG

ASUERO, AG

机构：

[1] Department of Analytical Chemistry, University of Seville

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 93卷 / 1-3期

关键词：

SOLVENT CLASSIFICATION; HILDEBRAND SOLUBILITY PARAMETER; REVERSED-PHASE HPLC; OPTIMIZATION; SIMPLEX LATTICE DESIGN;

D O I：

10.1016/0378-5173(93)90176-G

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Retention in HPLC is described in terms of Hildebrand solubility parameters. A set of solvents commonly used in reversed-phase HPLC was classified into selectivity groups by using the extended Hildebrand solubility parameters as descriptors. Optimization rules according to this system are given for improving the selectivity of separation.

引用

页码：183 / 188

页数：6

共 14 条

[1]

Akhnazarova S, 1982, EXPT OPTIMIZATION CH, P245

[2]

ARIES RE, 1991, CHEM BRIT, V27, P821

[3] SOLUBILITY PARAMETERS [J].