LIDOCAINE REDUCES THE HYPOXIA-INDUCED RELEASE OF AN EXCITATORY AMINO-ACID ANALOG FROM RAT STRIATAL, SLICES IN SUPERFUSION

被引：8

作者：

DIAZ, L ^{[1
]}

GOMEZ, A ^{[1
]}

BUSTOS, G ^{[1
]}

机构：

[1] PONTIFICIA UNIV CATOLICA CHILE, FAC CIENCIAS BIOL, FARMACOL BIOQUIM LAB, SANTIAGO, CHILE

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1995年 / 19卷 / 05期

关键词：

CEREBRAL HYPOXIA; EXCITATORY AMINO ACIDS; EXCITOTOXICITY; LIDOCAINE;

D O I：

10.1016/0278-5846(95)00122-C

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Lidocaine has been extensively investigated as a potential neuroprotective drug against ischemia-induced neurodegeneration without reaching any satisfactory conclusion. 2. The present work evaluates the effect of lidocaine -17 mu M- on the hypoxia-induced release of tritiated D-aspartate from rat striatal slices in superfusion. 3. Hypoxia resulted in a significant increase in the amount of D-aspartate released from striatal slices preloaded with the tritiated excitatory amino acid analog. 4. The addition of lidocaine to the superfusion solution resulted in a drastic reduction in the amount of D-aspartate release evoked by hypoxia, rendering it close to normal values.

引用

页码：943 / 953

页数：11

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