MOLECULAR-CLONING, SEQUENCE-ANALYSIS AND CODING ASSIGNMENT OF THE MAJOR INNER CAPSID PROTEIN GENE OF HUMAN GROUP-C ROTAVIRUS

被引：19

作者：

COOKE, SJ ^{[1
]}

LAMBDEN, PR ^{[1
]}

CAUL, EO ^{[1
]}

CLARKE, IN ^{[1
]}

机构：

[1] PUBL HLTH LAB,REG VIRUS LAB,BRISTOL BS2 8EL,ENGLAND

来源：

VIROLOGY | 1991年 / 184卷 / 02期

关键词：

D O I：

10.1016/0042-6822(91)90452-H

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The VP6 gene of human group C rotavirus was cloned and sequenced. Hybridization to the human group C and the porcine group C/Cowden dsRNA genomes assigned this coding sequence to segment 5. The complete human VP6 sequence contained an open reading frame of 1185 nucleotides (395 amino acids; deduced Mr 44,669 Da). The protein sequence demonstrated low homology with the group A VP6 sequences (41.7 to 42.7%) and high homology (88.9%) with the porcine group C VP6 sequence. However, the protein sequence alignments revealed a region of 10 amino acids that were significantly different between the human and the porcine group C viruses. © 1991.

引用

页码：781 / 785

页数：5

共 32 条

[1] PORCINE PARAROTAVIRUS - DETECTION, DIFFERENTIATION FROM ROTAVIRUS, AND PATHOGENESIS IN GNOTOBIOTIC PIGS
BOHL, EH
SAIF, LJ
THEIL, KW
AGNES, AG
CROSS, RF
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1982, 15 (02) : 312 - 319
[2] COMPARATIVE SEQUENCE-ANALYSIS OF ROTAVIRUS GENOMIC SEGMENT 6 - THE GENE SPECIFYING VIRAL SUBGROUP-1 AND SUBGROUP-2
BOTH, GW
SIEGMAN, LJ
BELLAMY, AR
IKEGAMI, N
SHATKIN, AJ
FURUICHI, Y
[J]. JOURNAL OF VIROLOGY, 1984, 51 (01) : 97 - 101
[3] SEQUENCE-ANALYSIS OF THE GENE (6) ENCODING THE MAJOR CAPSID PROTEIN (VP6) OF GROUP-C ROTAVIRUS - HIGHER THAN EXPECTED HOMOLOGY TO THE CORRESPONDING PROTEIN FROM GROUP-A VIRUS
BREMONT, M
CHABANNEVAUTHEROT, D
VANNIER, P
MCCRAE, MA
COHEN, J
[J]. VIROLOGY, 1990, 178 (02) : 579 - 583
[4] PREVALENCE OF ANTIBODY TO TYPICAL AND ATYPICAL ROTAVIRUSES IN PIGS
BRIDGER, JC
BROWN, JF
[J]. VETERINARY RECORD, 1985, 116 (02) : 50 - 50
[5] BRIDGER JC, 1987, CIBA F SYMP, V128, P5
[6] GROUP-C ROTAVIRUSES IN HUMANS
BRIDGER, JC
PEDLEY, S
MCCRAE, MA
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1986, 23 (04) : 760 - 763
[7] BROWN DWG, 1989, LANCET, V2, P737
[8] GROUP-C ROTAVIRUS ASSOCIATED WITH FATAL ENTERITIS IN A FAMILY OUTBREAK
CAUL, EO
ASHLEY, CR
DARVILLE, JM
BRIDGER, JC
[J]. JOURNAL OF MEDICAL VIROLOGY, 1990, 30 (03) : 201 - 205
[9] CHEN GM, 1985, LANCET, V2, P1123
[10] CLONING OF BOVINE ROTAVIRUS (RF STRAIN) - NUCLEOTIDE-SEQUENCE OF THE GENE CODING FOR THE MAJOR CAPSID PROTEIN
COHEN, J
LEFEVRE, F
ESTES, MK
BREMONT, M
[J]. VIROLOGY, 1984, 138 (01) : 178 - 182

← 1 2 3 4 →