GENETIC TRANSMISSION OF MIGRAINE WITHOUT AURA - A STUDY OF 68 FAMILIES

被引：16

作者：

DAMICO, D

LEONE, M

MACCIARDI, F

VALENTINI, S

BUSSONE, G ^{[1
]}

机构：

[1] IST NAZL NEUROL C BESTA,CTR CEFALEE,VIA CELORIA 11,I-20133 MILAN,ITALY

[2] UNIV MILAN,OSPED SAN RATFAELE,PSICHIAT CLIN 3,I-20122 MILAN,ITALY

来源：

ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1991年 / 12卷 / 06期

关键词：

MIGRAINE WITHOUT AURA; GENETIC HYPOTHESIS; FAMILY HISTORY; SEX-LIMITED TRANSMISSION;

D O I：

10.1007/BF02336955

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

68 randomly selected patients with migraine without aura (M) and 4 generations of their relatives (N = 394) were studied in order to probe the genetic hypothesis of migraine. Significantly more of the probands were women and M was significantly more frequent among female relatives. Earlier onset was commoner among male probands. A genetic component of M is indicated by the very high frequency of at least one affected relative (85.3%) and by a disease prevalence that is similar among both first and second degree relatives. A simple autosomal mode of transmission seems unlikely from analysis of the data on the affected relatives, while a "sex-limited" transmission mode is suggested.

引用

页码：581 / 584

页数：4

共 19 条

[1] BAROLIN GS, 1969, FORTSCHR NEUROL P I, V37, P521
[2] Migraine
Bassoe, P
[J]. JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1933, 101 : 599 - 605
[3] BILLE B, 1962, ACTA PAED STOCK S136, V51, P1, DOI DOI 10.1111/J.1651-2227.1962.TB06591.X
[4] COUCH JR, 1986, NEUROLOGY, V36, P99
[5] DALSGAARDNIELSE.T, 1962, ACTA NEUROL SCAND, V41, P287
[6] SEGREGATION ANALYSIS OF MIGRAINE IN 128 FAMILIES
DEVOTO, M
LOZITO, A
STAFFA, G
DALESSANDRO, R
SACQUEGNA, T
ROMEO, G
[J]. CEPHALALGIA, 1986, 6 (02) : 101 - 105
[7] GOODELL M, 1954, ARCH NEUROL PSYCHIAT, V72, P325
[8] GOWERS WR, 1898, MANUAL DISEASE NERVO, V2, P837
[9] HARVALD B, 1956, Dan Med Bull, V3, P150
[10] HEYCK M, 1956, THESIS STUTTGART

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