LONG-TERM TREATMENT WITH GABAPENTIN FOR PARTIAL EPILEPSY

被引：58

作者：

OJEMANN, LM

WILENSKY, AJ

TEMKIN, NR

CHMELIR, T

RICKER, BA

WALLACE, J

机构：

[1] UNIV WASHINGTON,SCH MED,CTR EPILEPSY,DEPT NEUROL SURG,SEATTLE,WA 98195

[2] UNIV WASHINGTON,SCH PUBL HLTH & COMMUNITY MED,DEPT BIOSTAT,SEATTLE,WA 98195

[3] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT DIV,ANN ARBOR,MI 48106

来源：

EPILEPSY RESEARCH | 1992年 / 13卷 / 02期

关键词：

LONG-TERM TREATMENT; GABAPENTIN; PARTIAL EPILEPSY;

D O I：

10.1016/0920-1211(92)90072-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Gabapentin was studied as an open-label 'add-on' antiepileptic drug in 35 patients with partial seizures. Follow-up at 6 months, 12 months, 18 months, and 24 months is reported. There was a trend toward improvement in simple (SPS) and complex partial seizures with it reaching significance for SPS at 12 and 24 months and for the weighted combination of seizures at 3 months. Five of nine patients were subsequently successfully converted to gabapentin monotherapy. Of those five, one is now seizure free and three are significantly improved since baseline. One remains with unchanged seizure frequency compared to baseline, but is experiencing less toxicity than at that time. This long-term observation suggests that the short-term effect demonstrated in blinded studies continues and that indeed some patients with refractory epilepsy can be maintained on gabapentin alone. Based on these findings, double-blind monotherapy trials of this drug are presently being conducted.

引用

页码：159 / 165

页数：7