RECENT DEVELOPMENTS IN SUPERCRITICAL-FLUID CHROMATOGRAPHY MASS-SPECTROMETRY COUPLING

After some time of stagnation, research in supercritical fluid chromatography (SFC)-mass spectrometry (MS) coupling has been recently revived by investigations into the use of atmospheric pressure ionisation (API) techniques. Following a short introduction into the historical development, the present state of the art in SFC and the actual trends in the field of SFC-MS, the different interfacing methods are presented briefly discussing its advantages and drawbacks. Special attention is given to new results and recent developments including a survey of applications reported during the last few years.