6-MONTH OPEN TRIAL WITH ZIMELIDINE IN ALCOHOL-DEPENDENT PATIENTS - REDUCTION IN DAYS OF ALCOHOL INTAKE

被引：11

作者：

BALLDIN, J ^{[1
]}

BERGGREN, U ^{[1
]}

BOKSTROM, K ^{[1
]}

ERIKSSON, M ^{[1
]}

GOTTFRIES, CG ^{[1
]}

KARLSSON, I ^{[1
]}

WALINDER, J ^{[1
]}

机构：

[1] LINKOPING UNIV,DEPT PSYCHIAT,LINKOPING,SWEDEN

来源：

DRUG AND ALCOHOL DEPENDENCE | 1994年 / 35卷 / 03期

关键词：

ALCOHOL DEPENDENCE; PSYCHOSOCIAL THERAPY; ZIMELIDINE; ALCOHOL INTAKE;

D O I：

10.1016/0376-8716(94)90081-7

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

In an open study, 14 alcohol-dependent male patients were treated with the selective serotonin reuptake inhibitor (SSRI) Zimelidine, 200 mg daily, for six months. They were given psychosocial therapy before and during the study. The number of days of alcohol intake was statistically significantly reduced from a mean of 14 days per month before to 1-5 days during drug treatment. No effect was observed on the amount of daily alcohol intake on drinking days. No tolerance to the effect of Zimelidine was observed during the study. The findings suggest an effect of combined psychosocial support with SSRI treatment that seems to be of clinical significance.

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收藏

页码：245 / 248

页数：4

相关论文

共 10 条

[1] A RATING-SCALE FOR ASSESSMENT OF ALCOHOL-WITHDRAWAL PSYCHOPATHOLOGY (AWIP) [J].

BOKSTROM, K ;

BALLDIN, J .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1992, 16 (02) :241-249

[2] EFFECT OF FLUOXETINE ON ALCOHOL-CONSUMPTION IN MALE ALCOHOLICS [J].

GORELICK, DA ;

PAREDES, A .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1992, 16 (02) :261-265

[3]

Naranjo C A, 1989, Recent Dev Alcohol, V7, P255

[4] THE SEROTONIN UPTAKE INHIBITOR CITALOPRAM ATTENUATES ETHANOL INTAKE [J].

NARANJO, CA ;

SELLERS, EM ;

SULLIVAN, JT ;

WOODLEY, DV ;

KADLEC, K ;

SYKORA, K .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1987, 41 (03) :266-274

[5] DIFFERENTIAL-EFFECTS OF VIQUALINE ON ALCOHOL INTAKE AND OTHER CONSUMMATORY BEHAVIORS [J].

NARANJO, CA ;

SULLIVAN, JT ;

KADLEC, KE ;

WOODLEYREMUS, DV ;

KENNEDY, G ;

SELLERS, EM .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1989, 46 (03) :301-309

[6] ZIMELIDINE-INDUCED VARIATIONS IN ALCOHOL INTAKE BY NONDEPRESSED HEAVY DRINKERS [J].

NARANJO, CA ;

SELLERS, EM ;

ROACH, CA ;

WOODLEY, DV ;

SANCHEZCRAIG, M ;

SYKORA, K .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1984, 35 (03) :374-381

[7] CITALOPRAM DECREASES DESIRABILITY, LIKING, AND CONSUMPTION OF ALCOHOL IN ALCOHOL-DEPENDENT DRINKERS [J].

NARANJO, CA ;

POULOS, CX ;

BREMNER, KE ;

LANCTOT, KL .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1992, 51 (06) :729-739

[8] FLUOXETINE DIFFERENTIALLY ALTERS ALCOHOL INTAKE AND OTHER CONSUMMATORY BEHAVIORS IN PROBLEM DRINKERS [J].

NARANJO, CA ;

KADLEC, KE ;

SANHUEZA, P ;

WOODLEYREMUS, D ;

SELLERS, EM .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1990, 47 (04) :490-498

[9] ADVERSE REACTIONS IN CONNECTION WITH ZIMELDINE TREATMENT - A REVIEW [J].

NILSSON, BS .

ACTA PSYCHIATRICA SCANDINAVICA, 1983, 68 :115-119

[10] 5-HT AND ALCOHOL-ABUSE [J].

SELLERS, EM ;

HIGGINS, GA ;

SOBELL, MB .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (02) :69-75