RIBOSOME BIOGENESIS - NONRANDOM ADDITION OF STRUCTURAL PROTEINS TO 50S SUBUNITS

被引：10

作者：

SELLS, BH

DAVIS, FC

机构：

[1] Department of Biochemistry, St. Jude Hospital, University of Tennessee

来源：

SCIENCE | 1968年 / 159卷 / 3820期

关键词：

D O I：

10.1126/science.159.3820.1240

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Assemblage of structural proteins into 50S subunits was examined in Escherichia coli recovering from chloramphenicol treatment. Cells previously labeled with H3-leucine for three generations were incubated for 30 minutes with chloramphenicol. Proteins synthesized during the initial 5 minutes of recovery from chloramphenicol treatment were labeled with C13-leucine. Marked variation in the ratios of C14 to H3-leucine in ribosomal protein occurred in cells that had been treated with chloramphenicol; untreated cells displayed little variation. The results suggest that ribosomal proteins are assembled into 50S subunits in a nonrandom manner.

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页码：1240 / &

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