INTERMITTENT VERSUS CONTINUOUS NEUROLEPTIC TREATMENT IN A RAT MODEL

被引:38
作者
GLENTHOJ, B [1 ]
HEMMINGSEN, R [1 ]
ALLERUP, P [1 ]
BOLWIG, TG [1 ]
机构
[1] UNIV COPENHAGEN,BISPEBJERG HOSP,DEPT PSYCHIAT,DK-2100 COPENHAGEN,DENMARK
关键词
(Animal models); Drug holidays (rat); Haloperidol (intermittent); Oral dyskinesia; Sensitization (pharmacological); Tardive dyskinesia; Zuclopenthixol (intermittent);
D O I
10.1016/0014-2999(90)94191-Y
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The treatment schedule for neuroleptic therapy is of relevance when evaluating the development of side-effects. Seventy-five rats were treated discontinuously or continuously with the predominantly dopamine D2 receptor blocker haloperidol or the combined dopamine D1/D2 receptor blocker zuclopenthixol for 15 weeks. During and after treatment, a broad spectrum of behavioural parameters including vacuous chewing movements and tongue protrusions were observed. Discontinuous neuroteptic treatment as opposed to continuous neuroleptic treatment produced a significant long-lasting increase in oral activity. The changes were most pronounced in haloperidol-treated rats. The differences observed may have methodological implications for animal models of neuroleptic-induced movement disorders. Our finding are consistent with the hypothesis that pharmacological sensitization to the dyskinetic side-effects of neuroleptics develops when the drug effect is allowed to wear off between repeated administration. © 1990.
引用
收藏
页码:275 / 286
页数:12
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