DUNAIMYCINS, A NEW COMPLEX OF SPIROKETAL 24-MEMBERED MACROLIDES WITH IMMUNOSUPPRESSIVE ACTIVITY .2. ISOLATION AND ELUCIDATION OF STRUCTURES

被引：23

作者：

HOCHLOWSKI, JE

MULLALLY, MM

BRILL, GM

WHITTERN, DN

BUKO, AM

HILL, P

MCALPINE, JB

机构：

[1] Pharmaceutical Products Research and Development, Abbott Laboratories, Abbott Park

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 12期

关键词：

D O I：

10.7164/antibiotics.44.1318

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel complex of antifungal and immunosuppressant compounds has been isolated from the fermentation broth and mycelia of two strains of Streptomyces diastatochromogenes. The structures of eight related components were determined employing ID and 2D homonuclear and heteronuclear NMR spectroscopy and mass spectrometry. These structures represent the first reported spiroketal 24-membered macrolide natural products related to the common 26-membered oligomycins.

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页码：1318 / 1330

页数：13

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