MAGNESIUM-SULFATE SUBCUTANEOUSLY INJECTED PROTECTS AGAINST KAINATE-INDUCED CONVULSIONS AND NEURODEGENERATION - INVIVO STUDY ON THE RAT HIPPOCAMPUS

被引：45

作者：

WOLF, G

FISCHER, S

HASS, P

ABICHT, K

KEILHOFF, G

机构：

[1] MED ACAD MAGDEBURG,INST CLIN CHEM,O-3034 MAGDEBURG,GERMANY

[2] MED ACAD MAGDEBURG,DIAGNOST LAB,O-3034 MAGDEBURG,GERMANY

来源：

NEUROSCIENCE | 1991年 / 43卷 / 01期

关键词：

D O I：

10.1016/0306-4522(91)90413-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Kainate, an agonist of a unique subclass of glutamate receptors (kainate receptor), was injected intracerebroventricularly in rats to induce convulsive reactions and hippocampal damage in order to model glutamate-mediated brain injury. Rats treated with magnesium sulfate (subcutaneously injected, up to 600 mg/kg) were found to be protected from kainate neurotoxicity depending on the dose and time of application. Results were largely consistent with those obtained previously by using quinolinate as an excitotoxic N-methyl-D-asparate-receptor agonist. Magnesium is discussed as being a natural and relatively safe therapeutic in cases of glutamate-induced (hypoxic, ischemic, traumatic, or convulsive) disorders of the brain.

引用

页码：31 / 34

页数：4

共 26 条

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